Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I ) in Complex with KNI-10075
收藏Protein Data Bank Japan2023-08-30 更新2026-03-21 收录
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Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I ) in Complex with KNI-10075 Descriptor: (4R)-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-3-(methyl sulfonyl)-L-alanyl}amino)-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, GLYCEROL, Protease Authors: Armstrong, A.A, Lafont, V, Kiso, Y, Freire, E, Amzel, L.M. Deposit date: 2007-04-17 Release date: 2007-05-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Compensating enthalpic and entropic changes hinder binding affinity optimization. Chem.Biol.Drug Des., 69, 2007
与KNI-10075结合的HIV-1蛋白酶（Q7K、L33I、L63I突变体）的晶体结构
描述符：(4R)-N-[(1S,2R)-2-羟基-2,3-二氢-1H-茚-1-基]-3-[(2S,3S)-2-羟基-3-{N-[(异喹啉-5-氧基)乙酰基]-3-(甲磺酰基)-L-丙氨酰基}氨基)-4-苯基丁酰基]-5,5-二甲基-1,3-噻唑烷-4-甲酰胺、甘油、蛋白酶
作者：Armstrong A.A.、Lafont V.、Kiso Y.、Freire E.、Amzel L.M.
保藏日期：2007-04-17
发布日期：2007-05-08
最后修改日期：2023-08-30
检测方法：X射线衍射（分辨率1.9 Å）
引用文献：补偿焓变与熵变阻碍结合亲和力优化。Chem.Biol.Drug Des., 69, 2007
创建时间：
2007-04-17
