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A multicentric randomized phase II study evaluating dual targeting of the EGFR using the combination of cetuximab and afatinib versus cetuximab alone in patients with chemotherapy refractory wtKRAS metastatic colorectal cancer.

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Primary objectives: Non Progression rate at 6 months Primary endpoints: The primary endpoint non progression rate will be presented by the percentage of patients without progression at 6 months with the 95% confidence interval.

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2012-05-15
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