The effect of attenuated Salmonella typhimurium on the tumor epithelium in mouse colorectal cancer model

Bacterial cancer therapy (BCT) shows great promise for treatment of solid tumors, yet basic mechanisms of bacterial-induced tumor suppression remain undefined. We aimed to better understand the tumor epithelium-targeted mechanisms of BCT by using mouse models of intestinal tumorigenesis to assess the effectiveness and mechanisms of treatment with aromatase A-deficient Salmonella typhimurium (STm) delivered by oral gavage. RNAseq using normal colon tissue or colon tumor induced by AOM/DSS, treated or non-treated with aromatase A-deficient STm delivered by oral gavage