Additional file 3 of Bicodon bias can determine the role of synonymous SNPs in human diseases

Table S1. Genetic diseases and sSNPs. The first column corresponds to the disease or genetic trait. The second and third columns correspond to the associated gene and SNP (where both can be more than one), respectively. Each SNP affects only one codon (third SNP row), but two bicodons, when the mutation is in the P-site (first SNP row), and when the mutation is in the A-site (second SNP row). Fourth, fifth, sixth and seventh columns, refer to the starting bicodon, list the bicodon sequence, the p-value, the residual score ( χ 2 = χ L 2 + χ H 2 $\chi ^{2}=\chi _{L}^{2}+ \chi _{H}^{2}$ ) and π value, respectively. The following four columns, refer to the resulting bicodon, list the bicodon sequence, the log-transformed p-value, the residual score and π value, respectively. The following three columns enumerate the relative p-value, the pause propensity variation, Δ π, and the corresponding Z-score due to the synonymous bicodon variant. The last two columns contain a summarized result of our analysis for each disease and the related references. (XLS 41 kb)