Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).

Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile). Descriptor: (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, ALK TYROSINE KINASE RECEPTOR Authors: McTigue, M, Deng, Y.-L, Liu, W, Brooun, A, Stewart, A. Deposit date: 2015-07-22 Release date: 2016-06-08 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Resensitization to Crizotinib by the Lorlatinib Alk Resistance Mutation L1198F. N.Engl.J.Med., 374, 2016

C1156Y突变体人类间变性淋巴瘤激酶（Anaplastic Lymphoma Kinase, ALK）与PF-06463922（(10R)-7-氨基-12-氟-2,10,16-三甲基-15-氧代-10,15,16,17-四氢-2H-8,4-(亚甲基)吡唑并[4,3-h][2,5,11]苯并氧二氮杂环十四烷-3-腈）的复合物结构。描述符：(10R)-7-氨基-12-氟-2,10,16-三甲基-15-氧代-10,15,16,17-四氢-2H-8,4-(亚甲基)吡唑并[4,3-h][2,5,11]苯并氧二氮杂环十四烷-3-腈、ALK酪氨酸激酶受体。作者：McTigue, M、Deng, Y.-L、Liu, W、Brooun, A、Stewart, A。提交日期：2015-07-22；发布日期：2016-06-08；最后修改日期：2024-01-10。实验方法：X射线衍射（分辨率1.6 Å）。引用文献：《洛拉替尼ALK耐药突变L1198F可使患者对克唑替尼复敏》（Resensitization to Crizotinib by the Lorlatinib Alk Resistance Mutation L1198F），《新英格兰医学杂志》（N. Engl. J. Med.），第374卷，2016年。