Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin Descriptor: 1,2-ETHANEDIOL, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, Activin receptor type-2A, ... Authors: Chaikuad, A, Alfano, I, Mahajan, P, Cooper, C.D.O, Sanvitale, C, Vollmar, M, Krojer, T, Muniz, J.R.C, Raynor, J, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) Deposit date: 2010-12-24 Release date: 2011-02-09 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation. J.Biol.Chem., 290, 2015

IIA型激活素受体（Activin receptor type-IIA, ACVR2A）激酶结构域与多马索林（dorsomorphin）复合物的晶体结构
描述：1,2-乙二醇、6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-a]嘧啶、IIA型激活素受体-2A……
作者：Chaikuad, A、Alfano, I、Mahajan, P、Cooper, C.D.O、Sanvitale, C、Vollmar, M、Krojer, T、Muniz, J.R.C、Raynor, J、von Delft, F、Weigelt, J、Arrowsmith, C.H、Edwards, A.M、Bountra, C、Bullock, A，结构基因组学联盟（Structural Genomics Consortium, SGC）
存入日期：2010-12-24
发布日期：2011-02-09
最后修改日期：2023-09-13
实验方法：X射线衍射法（分辨率1.96 Å）
引用文献：《小分子化合物多马索林与LDN-193189抑制肌抑素/GDF8信号通路并促进功能性成肌细胞分化》，《生物化学杂志》，2015年，第290卷