Biomimetic Desymmetrization of a Carboxylic Acid
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https://figshare.com/articles/dataset/Biomimetic_Desymmetrization_of_a_Carboxylic_Acid/5853732
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资源简介：
The
enantioselective desymmetrization of carboxylic acids by chiral
Brønsted base catalysis is reported, leading to bridged bicyclic
lactones with up to 94% ee. Crystallographic analysis of a substrate–catalyst
complex suggests an origin of stereocontrol, reminiscent of functional
Brønsted bases in biological settings, and enabled reaction optimization.
The products contain an all-carbon quaternary stereocenter and can
be derivatized to functionalized cyclopentanes.
创建时间：
2018-02-05
