G1 to S cell cycle control
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In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&
在G1期，存在两种DNA损伤反应途径，即依赖p53的途径和不依赖p53的途径。依赖p53的反应通过p53蛋白介导的CKI编码基因的上调来抑制CDKs，而p53非依赖性机制则通过Cdk2的抑制性T14Y15磷酸化来抑制CDKs。G1期DNA损伤检查点的失败会导致受损模板的突变性复制以及其他复制缺陷。来源：Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&
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