Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG)in complex with rosiglitazone

Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG)in complex with rosiglitazone Descriptor: 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), GLYCEROL, ... Authors: Chaikuad, A, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2020-11-06 Release date: 2020-11-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Endogenous vitamin E metabolites mediate allosteric PPAR gamma activation with unprecedented co-regulatory interactions. Cell Chem Biol, 28, 2021

过氧化物酶体增殖物激活受体γ（Peroxisome proliferator-activated receptor gamma, PPARG）与罗格列酮（rosiglitazone）结合的晶体结构。描述内容：2,4-噻唑烷二酮，5-[[4-[2-(甲基-2-吡啶基氨基)乙氧基]苯基]甲基]-（9CL）、甘油（GLYCEROL）等。作者：Chaikuad A、Merk D、Knapp S，结构基因组学联盟（Structural Genomics Consortium, SGC）。提交日期：2020-11-06，发布日期：2020-11-25，最后修改日期：2024-01-31。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.74 Å）。引用文献：内源性维生素E代谢物通过前所未有的协同调控相互作用介导PPARγ变构激活，《细胞化学与生物学（Cell Chem Biol）》，2021年，第28卷。