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High expression of uracil DNA glycosylase determines C to T substitution in human pluripotent stem cells

NIAID Data Ecosystem2026-03-13 收录

碱基编辑

多能干细胞

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA787724 数据链接链接失效反馈

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资源简介：

editing efficiency of base editors in human pluripotent stem cells

应用场景：

创建时间：

2021-12-10

基因组学

多能干细胞

Genome binding/occupancy profiling by high throughput sequencing Examination of genome-wide ATAC-seq in human embryonic stem cells and different classes of induced pluripotent stem cells.

Research Data Australia120

Mus musculus strain:C57BL6/J Genome sequencing and assembly. Mus musculus strain:C57BL6/J

碱基编辑

突变小鼠模型

Using a programmable cytidine deaminase which is called Base Editor, we created nonsense mutation in Dmd or Tyr gene in mice.

NIAID Data Ecosystem90

A split and inducible adenine base editor for precise in vivo base editing

碱基编辑

基因编辑技术

Raw amplicon and RNA-seq data

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Function of 5C medium in somatic cell reprogramming

细胞重编程

多能干细胞

We induced reprogramming by mES and 5C medium, and collected mRNA profiles of the GFP+ and GFP- reprogramming cells sorted by FACS. We found that 5C iPSCs showed differences with mES iPSCs, with diffe

干细胞与再生医学数据中心2022-02-20 更新90

Increase base editing efficiency and product variety through fusion of Cas9 nickase to cytosine and adenosine deaminases

碱基编辑

CRISPR-Cas9

Base editors, which are created through fusion of Cas9 nickase to either cytidine or adenine deaminase, efficiently catalyze site-specific nucleotide conversions with minimal indel rates1, 2. However,

NIAID Data Ecosystem50

High expression of uracil DNA glycosylase determines C to T substitution in human pluripotent stem cells

资源简介：

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