Crystal structure of Jak2 complexed with a potent 2,8-diaryl-quinoxaline inhibitor

Crystal structure of Jak2 complexed with a potent 2,8-diaryl-quinoxaline inhibitor Descriptor: N-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide, Tyrosine-protein kinase JAK2 Authors: Tavares, G.A, Pissot-Soldermann, C, Gerspacher, M, Furet, P, Kroemer, M. Deposit date: 2010-02-05 Release date: 2010-04-28 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors Bioorg.Med.Chem.Lett., 20, 2010JAK2结合强效2,8-二芳基喹喔啉抑制剂的晶体结构 配体描述：N-甲基-4-[3-(3,4,5-三甲氧基苯基)喹喔啉-5-基]苯磺酰胺；靶标蛋白：酪氨酸蛋白激酶JAK2（Tyrosine-protein kinase JAK2） 作者：Tavares, G.A.、Pissot-Soldermann, C.、Gerspacher, M.、Furet, P.、Kroemer, M. 提交日期：2010-02-05 发布日期：2010-04-28 最后修改日期：2024-10-30 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2 Å 引用文献：《Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors》，刊载于《Bioorg.Med.Chem.Lett.》，第20卷，2010年