Crystal structure of SARS-CoV-2 main protease A191T mutant in complex with an inhibitor 5h

Crystal structure of SARS-CoV-2 main protease A191T mutant in complex with an inhibitor 5h Descriptor: 3C-like proteinase nsp5, N-[(2S)-1-({(1S,2S)-1-(1,3-benzothiazol-2-yl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide Authors: Bulut, H, Hattori, S, Hayashi, H, Hasegawa, K, Li, M, Wlodawer, A, Tamamura, H, Mitsuya, H. Deposit date: 2024-02-23 Release date: 2024-04-24 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Structural and virologic mechanism of the emergence of resistance to M pro inhibitors in SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 121, 2024SARS-CoV-2主蛋白酶A191T突变体与抑制剂5h复合物的晶体结构。描述符：3C样蛋白酶（3C-like proteinase）nsp5，N-[(2S)-1-({(1S,2S)-1-(1,3-苯并噻唑-2-基)-1-羟基-3-[(3S)-2-氧代吡咯烷-3-基]丙-2-基}氨基)-4-甲基-1-氧代戊烷-2-基]-4-甲氧基-1H-吲哚-2-甲酰胺；作者：Bulut, H、Hattori, S、Hayashi, H、Hasegawa, K、Li, M、Wlodawer, A、Tamamura, H、Mitsuya, H.；存放日期：2024-02-23；发布日期：2024-04-24；最后修改日期：2024-11-13；实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.49埃；引用文献：《SARS-CoV-2对Mpro抑制剂产生耐药性的结构与病毒学机制》，《美国国家科学院院刊》，121卷，2024年