Antineoplastic Agents. 590. X-ray Crystal Structure of Dolastatin 16 and Syntheses of the Dolamethylleuine and Dolaphenvaline Units
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https://figshare.com/articles/dataset/Antineoplastic_Agents_590_X_ray_Crystal_Structure_of_Dolastatin_16_and_Syntheses_of_the_Dolamethylleuine_and_Dolaphenvaline_Units/2647477
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资源简介：
Three advances necessary to bring dolastatin 16 (1) into full-scale preclinical development as an anticancer drug have been accomplished. The X-ray crystal structure of dolastatin 16 has been solved, which allowed stereoselective syntheses of its two new amino acid units, dolamethylleuine (Dml) and dolaphenvaline (Dpv), to be completed. The X-ray crystal structures of synthetic Z-Dml and TFA-Dpv have also been completed.
创建时间：
2016-02-23
