Replication Data for: Characterizing Active and Inactive Brown Adipose Tissue in Adult Humans Using PET-CT and MR Imaging

The purpose of this study is to characterize both active and inactive supraclavicular brown adipose tissue (BAT) in adults, and compare the values to those of subcutaneous white adipose tissue (WAT). We obtained 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) with x-ray computed tomography (CT) and magnetic resonance imaging (MRI) scans of 25 healthy adults. To the best of our knowledge this is the first study to quantify PET-CT and MRI fat signal fraction (FSF) measures, and utilize a semi-automated algorithm to identify inactive and active BAT in the same adult subjects. Our findings support the use of these metrics to characterize and distinguish between BAT and WAT, and lay the foundation for future MRI analysis with the hope that someday MRI-based delineation of BAT can stand on its own.