Imaging (CEUS & MRI), clinical (neuroscores) and biological (mitochondria function) endpoints in a murine model of ischemic stroke (sham, pMCAO and tMCAO) treated with ciclosporin A (CsA)

The aims of this study were: (i) To evaluate mitochondrial dysfunctions (using CRC and OXPHOS analysis) in a murine model of MCAO (transient and permanent) using multimodal imaging (per-occlusion dynamic contrast-enhanced ultrasound (CEUS) assessment of the area-at-risk (AAR) and MRI at day 1 to evaluate infarct size) and neuroscore evaluation;(ii) To study CsA as a cytoprotective treatment potentially targeting mitochondria in the tMCAO model combining imaging approach, neuroscores assessment and mitochondrial function analyses (mPTP sensitivity to Ca2+ and OXPHOS).<br>