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Tumor-specific mechanism of Treg enrichment mediated by the integrin avb8

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE158031
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Subcutaneous tumors from mock transfected LLC or b8 transfected LLC were established on flanks of C57B/6 FoxP3-Ires GFP mice. Mice were treated with isotype control antibodies or anti-b8 and Tregs (CD4+ GFP+) were sorted, pooled and total RNA isolated for RNAseq. Three CD4+ GFP+ pools, each from 3-4 mice, for 3 conditions (Tregs from tumors from mock transfected LLC, b8 expressing LLC treated with isotype control or b8 expressing LLC treated with anti-b8 )
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2021-02-23
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