JMJD4 regulates PKM2 degradation of cardiomyocytes and is critical in the development of dilated cardiomyopathy

RNA-Seq results of adult mouse cardiomyocytes with Jmjd4 knockout and neonatal rat cardiomyocytes with Jmjd4 knockdown. To investigate the role of Jmjd4 in dilated cardiomyopathy, we performed gene expression profiling with RNA-Seq results from heart samples of MCM+ Jmjd4f/f and control Jmjd4f/f mice, as well as neonatal rat ventricuar cardiomyocytes (NRVCs) treated with si-Jmjd4 and si-NC control. Overall design: RNA-Seq analysis of Jmjd4 cKO mice heart tissue and Jmjd4 knock down NRVCs