Effect of Kdm4a knockdown (KD) on gene expression in mosue PTR NEPC cells derived from Pb-Cre+,Pten f/f, Trp53 f/f, Rb1 f/f NEPC mouse model

To investigate the role of KDM4A in the regulation of gene expression in NEPC cells, we established Kdm4a KD cell lines in which Kdm4a gene has been knocked down by shRNA. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different cells at two time points. Overall design: Comparative gene expression profiling analysis of RNA-seq data for PTR cells infected with non-targeting shRNA control and its KD derivatives (shKDM4A-#4).