Intensity response in key CST areas and control regions.

Mean intensity inside ROIs along the CST and in ALS independent white matter regions are shown. The absolute difference of the mean in patients versus controls is referenced to the total white matter intensity spread to allow comparability to other study settings. Significances are given as * (p<0.05), ** (p<0.01), ***(P<0.001) or as not significant (n.s.). The highest response was found in the left PLIC (8.7% higher intensity in patients than in controls). The non ALS disease related white matter regions did not significantly differ between patients and controls.