A new 1D Zn(II) coordination polymer containing pyridinyl-imidazolyl ligand: crystal structure and protective effect on dermatitis by reducing the inflammatory level
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A new coordination polymer of [Zn(bdc)(bimb)](DMF)(H<sub>2</sub>O)<sub>2</sub> (<b>1</b>, H<sub>2</sub>bdc = 1,4-dicarboxybenzene, bimb = 6,6'-bis(1H-benzo[d]imidazol-2-yl)-2,2'-bipyridine) has been successfully synthesized by reaction of Zn(NO<sub>3</sub>)<sub>2·</sub>6H<sub>2</sub>O, H<sub>2</sub>bdc and bimb in a mixed solvent of DMF and water at 80 °C for three days. Furthermore, an ultrasound synthesis technique has been implemented to reduce the particle size of the complex <b>1</b> to generate nanoscale <b>1</b> (denoted as nano <b>1</b>). We constructed the dermatitis mice model with DNFB-induction. The scoring index of the AD lesion in mice was evaluated after nano <b>1</b> treatment and the ELISA was used to measure the level of inflammatory medium after nano <b>1</b> exposure.
