Data deposition RE: Awinda et al. 2020. Br J Pharmacol.

Citation:Awinda PO, Bishaw Y, Watanabe M, Guglin MA, Campbell KS, Tanner BCW. (2020) Effects of mavacamten on Ca 2+ -sensitivity of contraction as sarcomere length varied in human myocardium. Br J Pharmacol. 1-13. doi: 10.1111/bph.15271.
From PubMed, with associated links:
PMID: 32960449PMCID: PMC7707091DOI: 10.1111/bph.15271

Data Files:Isometric force data. Data quality = 1, which represents all the data that was used in the manuscript. Summary Data too. File: Donor_Mava_Isometric_Force_pCa.xlsx
Summary File: Summary_Isometric_Force_pCa_Data.xlsx

Four parameter Hill fits for Force-pCa data (i.e. Fig. 3 & 4). Note--this is an Excel file with multiple tabs. SL = 1.9 is first tab, SL = 2.3 is second tab. File: Hill_Fits_Force_pCa_analysis.xlsx

Sinusoidal length perturbation analysis data. Frequency, Em (=elastic modulus), Vm (=viscous modulus), with Em_Fit and Vm_Fit representing fits to Eqn. 1 in the manuscript. DQ1 in the file name represents the data quality = 1, which represents all the data that was used in the manuscript. File: Donor_Sinusoid_Data.xlsx
Summary Sinusoidal Data Averages: Summary_Sinusoid_Em_Vm_Freq.xlsx

Parameters from fitting the sinusoidal vs. frequency data find the Min (=dip) and Max (=peak) Viscous modulus File: Dip_Peak_Viscous_Freq_Analysis.xlsx