Co-crystal of BACE1 with compound 0211

Co-crystal of BACE1 with compound 0211 Descriptor: Beta-secretase 1, N-[(2S,3R)-3-hydroxy-4-({(2S,3S)-3-hydroxy-1-[(2-methylpropyl)amino]-1-oxobutan-2-yl}amino)-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide Authors: Ghosh, A.K, Bhavanam, S.R, Yen, T.-C, Cardenas, E.L, Rao, K.V, Downs, D, Huang, X, Tang, J, Mescar, A.D. Deposit date: 2015-09-14 Release date: 2016-02-17 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.4651 Å) Cite: Design of Potent and Highly Selective Inhibitors for Human beta-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes. Chem Sci, 7, 2016BACE1与化合物0211共晶。描述符：β-分泌酶1（Beta-secretase 1），N-[(2S,3R)-3-羟基-4-({(2S,3S)-3-羟基-1-[(2-甲基丙基)氨基]-1-氧代丁烷-2-基}氨基)-1-苯基丁烷-2-基]-5-[甲基(甲磺酰基)氨基]-N'-[(1R)-1-苯乙基]苯-1,3-二甲酰胺；作者：Ghosh, A.K.、Bhavanam, S.R.、Yen, T.-C.、Cardenas, E.L.、Rao, K.V.、Downs, D.、Huang, X.、Tang, J.、Mescar, A.D.；存档日期：2015-09-14；发布日期：2016-02-17；最后修改日期：2024-11-20；测试方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.4651 Å；引用文献：《人源β-分泌酶2（Memapsin 1，2型糖尿病治疗靶点）的强效高选择性抑制剂设计》，《化学科学》（Chem Sci），第7卷，2016年