Role of epigenetics in the clinical evolution of COVID-19 disease. Epigenome-wide association study identifies markers of severe outcome.

We performed a whole-genome DNA methylation analysis using EPIC Illumina BeadArrays on a cohort of 187 “Italian” COVID-19 patients (123 mild and 64 severe) to identify epigenetic markers underlying the worst evolution of the disease (death or Intensive Care Unit admission for mechanical ventilation support). Genome-wide DNA methylation analysis of a cohort of COVID-19 patients with a different clinical evolution (123 mild vs 64 severe) using Illumina Human Methylation EPIC Beadchips.