Retinal proteomic analysis in rd10 mouse model of retinitis pigmentosa following heterozygous TAK1 deficiency using LC-MS/MS

To decipher the protective mechanisms underlying microglia specific heterozygous TAK1 deficiency in rd10 mouse model of retinitis pigmentosa, we analyzed the retinal proteomic profiles of normal C57BL/6J mice, tamoxifen-treated Cx3cr1CreER/+;Tak1fl/+, vehicle-treated rd10;Cx3cr1CreER/+;Tak1fl/+, and tamoxifen-treated rd10;Cx3cr1CreER/+;Tak1fl/+ mice using a data-independent acquisition-based mass spectrometry (DIA).