4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer Descriptor: 5-[2,4-DIHYDROXY-5-(1-METHYLETHYL)PHENYL]-N-ETHYL-4-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ISOXAZOLE-3-CARBOXAMIDE, HEAT SHOCK PROTEIN HSP 90-ALPHA Authors: Brough, P.A, Aherne, W, Barril, X, Borgognoni, J, Boxal, K, Cansfield, J.E, Cheung, K.M, Collins, I, Davies, N.G.M, Drysdale, M.J, Dymock, B, Eccles, S.A, Finch, H, Fink, A, Hayes, A, Howes, R, Hubbard, R.E, James, K, Jordan, A.M, Lockie, A, Martins, V, Massey, A, Matthews, T.P, McDonald, E, Northfield, C.J, Pearl, L.H, Prodromou, C, Ray, S, Raynaud, F.I, Roughley, S.D, Sharp, S.Y, Surgenor, A, Walmsley, D.L, Webb, P, Wood, M, Workman, P, Wright, L. Deposit date: 2007-09-24 Release date: 2007-12-11 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. J. Med. Chem., 51, 2008

4,5-二芳基异恶唑（4,5-Diaryl Isoxazole）热休克蛋白90（Hsp90）伴侣抑制剂：潜在抗癌治疗药物
描述项：5-[2,4-二羟基-5-(1-甲基乙基)苯基]-N-乙基-4-[4-(吗啉-4-基甲基)苯基]异恶唑-3-甲酰胺，热休克蛋白HSP 90-α
作者：Brough, P.A、Aherne, W、Barril, X、Borgognoni, J、Boxal, K、Cansfield, J.E、Cheung, K.M、Collins, I、Davies, N.G.M、Drysdale, M.J、Dymock, B、Eccles, S.A、Finch, H、Fink, A、Hayes, A、Howes, R、Hubbard, R.E、James, K、Jordan, A.M、Lockie, A、Martins, V、Massey, A、Matthews, T.P、McDonald, E、Northfield, C.J、Pearl, L.H、Prodromou, C、Ray, S、Raynaud, F.I、Roughley, S.D、Sharp, S.Y、Surgenor, A、Walmsley, D.L、Webb, P、Wood, M、Workman, P、Wright, L
存入日期：2007年9月24日
发布日期：2007年12月11日
最后修改日期：2023年12月13日
检测方法：X射线衍射（2埃）
引用文献：4,5-二芳基异恶唑Hsp90伴侣抑制剂：潜在抗癌治疗药物。《药物化学杂志》（J. Med. Chem.），第51卷，2008年