Netrin-UNC5B signaling

UNC-5 Homolog B (UNC5B) is a member of the dependence receptor family. It can induce two opposite intracellular signaling cascades depending on the presence or absence of the ligand and is thus capable of driving two opposing processes. UNC5B signaling has been implicated in several cancers, where it promotes cell death in the absence of its ligand netrin-1 and increases cell survival in its presence. In addition, inhibition of the ligand has been reported to decrease invasiveness and angiogenesis in tumors. UNC5B signaling pathway has also been reported to be involved in several processes such as neural development, developmental angiogenesis and inflammatory processes. Interaction of UNC5B with netrins activates various signaling modules including ERK1/ERK2, p38 MAPK signaling and PI3k-AKT pathway modules

UNC-5同源蛋白B（UNC5B）隶属于依赖性受体家族。根据配体（如netrin-1）的存在与否，UNC5B能够启动两种相反的细胞内信号级联反应，从而驱动两种对立的生物学过程。UNC5B信号通路与多种癌症的发生发展密切相关，在netrin-1缺失时，其可诱导细胞死亡，而在netrin-1存在时，则促进细胞存活。此外，抑制配体活性已被证实可降低肿瘤的侵袭性和血管生成。UNC5B信号通路还参与神经发育、发育性血管生成和炎症过程等多种生理和病理过程。UNC5B与netrin蛋白家族的相互作用，激活了包括ERK1/ERK2、p38 MAPK信号和PI3k-AKT途径在内的多种信号模块。