Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors
收藏Protein Data Bank Japan2024-11-27 更新2026-03-21 收录
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Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors Descriptor: 3-[(4R)-2'-amino-1',2,2-trimethyl-5'-oxo-1',2,3,5'-tetrahydrospiro[chromene-4,4'-imidazol]-6-yl]benzonitrile, Beta-secretase 1, NICKEL (II) ION Authors: Vigers, G.P.A, Smith, D. Deposit date: 2013-03-19 Release date: 2013-04-10 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid beta in a higher species. J.Med.Chem., 56, 2013
创建时间：
2013-03-19
