Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors

Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors Descriptor: 3-[(4R)-2'-amino-1',2,2-trimethyl-5'-oxo-1',2,3,5'-tetrahydrospiro[chromene-4,4'-imidazol]-6-yl]benzonitrile, Beta-secretase 1, NICKEL (II) ION Authors: Vigers, G.P.A, Smith, D. Deposit date: 2013-03-19 Release date: 2013-04-10 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid beta in a higher species. J.Med.Chem., 56, 2013螺环型β位淀粉样前体蛋白裂解酶1（BACE1）抑制剂 描述信息：3-[(4R)-2'-氨基-1',2,2-三甲基-5'-氧代-1',2,3,5'-四氢螺[色烯-4,4'-咪唑]-6-基]苯甲腈、β位分泌酶1、镍（II）离子 作者：Vigers, G.P.A、Smith, D. 提交日期：2013-03-19 发布日期：2013-04-10 最后修改日期：2024-11-27 测试方法：X射线衍射（分辨率1.8埃） 引用文献：《螺环型β位淀粉样前体蛋白裂解酶1（BACE1）抑制剂：从命中化合物到降低高等生物脑脊液（CSF）中淀粉样β水平》，《药物化学杂志》，56卷，2013年