Clinical and radiographic efficacy of LSTR with 3Mix-R antibiotic paste in paediatric patients aged 4-9 years at the Dr. René Puig Bentz Clinic, Universidad Nacional Pedro Henríquez Ureña.

In pediatric dentistry, it is common for children to require pulp therapies due to deep cavities that compromise pulp health. The objective of this research was to verify the clinical and radiographic effectiveness of the 3Mix-R paste, in order to increase treatment options and evaluate an alternative material that could replace tetracycline-derived antibiotic pastes, which have been shown to cause staining in the germs of successor teeth. The use of the 3Mix-R antibiotic paste, composed of metronidazole, ciprofloxacin, clindamycin, and distilled water, is proposed. This paste is rarely used due to the lack of research and the replacement of minocycline with clindamycin, which is prohibited by the International Association of Pediatric Dentistry (IAPD). To measure the effectiveness of 3Mix-R paste, it was compared with PTA paste, which has scientific evidence of its effectiveness. The study evaluated 20 cases, dividing the patients into two groups: 50% received 3Mix-R paste, and the other 50% received PTA paste, with clinical and radiographic follow-ups conducted two weeks, one month, and three months after the material's placement. The results of the general linear model (GLM) analysis showed no significant difference in the clinical and radiographic effectiveness pattern between the groups (p> 0.05), indicating equivalent effectiveness between both pastes. Additionally, chi-square analysis showed no significant difference in treatment responses according to the initial pulp diagnosis (p> 0.05). The study results conclude that treatment with 3Mix-R in primary molars demonstrates clinical and radiographic effectiveness over a three-month observation period, suggesting that 3Mix-R paste can be considered a viable alternative like PTA.