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A Concise Approach for the Total Synthesis of Pseudolaric Acid A

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NIAID Data Ecosystem2026-03-07 收录
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A new strategy for the stereoselective total synthesis of natural product pseudolaric acid A (1) was accomplished in 16 steps from commercially available starting material, featuring a samarium diiodide (SmI2)-mediated intramolecular alkene-ketyl radical cyclization and a ring-closing metathesis (RCM) reaction to stereoselectively cast the unusual trans-fused [5–7]-bicyclic core of pseudolaric acid A (1).

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2016-02-23
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