DELIVERY， CONSTRUCTION AND OPTIMIZATION OF SYSTEMS， METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND USE IN THERAPY
收藏国家林业和草原科学数据中心2023-02-12 更新2024-03-07 收录
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资源简介：
FIELD: biotechnology. SUBSTANCE: methods are proposed for modifying a eukaryotic organism by manipulating a target sequence in a genome locus of interest by using the CRISPR-Cas system， as well as a method of treating or inhibiting a condition caused by a defect in a target sequence， and a composition containing components of said system. EFFECT: present invention enables the change of genomic loci of the eukaryotic cell by using Cas9 nuclease fused with one or more nuclear localization sequences (NLS). 21 cl， 73 dwg， 35 tbl， 37 ex
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国家林业和草原科学数据中心
创建时间：
2023-02-12
