Cancer related variants list

We created a set of 71021 protein altering variants related to cancer.The list can be used to annotate or prioritize any mutation lists from Human sequencing experiment. Methods: We selected variants from COSMICv94 (GRCh38) where CNT > 2 excluding those flagged as SNP.The resulting dataset was further annotated using SNPEff (v5.1d) and Clinvar (20240325) using SnpSift (v5.1d).We filtered out all the 'Benign' and 'Likely_benign' as well as all the 'synomnimous_variants'. FOR RESEARCH USE ONLY COSMIC and Clinvar have usage policy restrictions. https://cancer.sanger.ac.uk/cosmic/licensehttps://www.ncbi.nlm.nih.gov/clinvar/docs/maintenance_use/