A High-dose of genistein down-regulates TGF-beta pathway genes in human uterine leiomyoma cells

ChEBI2012-04-30 更新2026-07-21 收录

子宫肌瘤分子机制

TGF-β信号通路调控

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-19477 数据链接链接失效反馈

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资源简介：

A High-dose of genistein down-regulates TGF-beta pathway genes in human uterine leiomyoma cells

创建时间：

2012-04-30

Genome-wide transcriptome regulation by progesterone receptor in primary leiomyoma cells

子宫肌瘤分子机制

激素受体转录组

Uterine leiomyomas (LM) affect up to 80% of all reproductive-age women. LM growth requires progesterone, progesterone receptor (PGR), and the maintenance and proliferation of a small (5%) stem cell po

NIAID Data Ecosystem130

RNA-seq in Hs578T cells stimulated with TGF-Ã

乳腺癌转录组学

TGF-β信号通路调控

Transforming growth factor-Ã (TGF-Ã) comprises a key component in the tumor microenvironment. It is reported that TGF-Ã can be pro-tumorigenic or anti-tumorigenic depending on various contexts. Som

NIAID Data Ecosystem100

Study of three-dimensional structure of chromatin through a 4C-seq experiment in mouse NSC shControl and shJMJD3 upon TGFβ treatment [Chst8]

染色质三维构象分析

TGF-β信号通路调控

In this study we analyzed how multiple enhancers arrange in the 3D-space to control the activation of a specific promoter. Specifically, we did a 4C-seq experiment on a ~374 Kb locus where enhancers a

NIAID Data Ecosystem70

LncRNA APTR promotes uterine leiomyoma cell proliferation by targeting ERα to activate the Wnt/β-catenin pathway. LncRNA APTR promotes uterine leiomyoma cell proliferation by targeting ERα to activate the Wnt/β-catenin pathway

子宫肌瘤分子机制

Wnt/β-catenin信号通路

The molecular mechanisms by which uterine leiomyoma (UL) cells proliferate are unclear. Long noncoding RNA (lncRNA) is reported to participate in the occurrence and development of gynecological cancer

NIAID Data Ecosystem120

Galunisertib (LY2157299), a transforming growth factor-β receptor I kinase inhibitor, attenuates acute pancreatitis in rats

急性胰腺炎

TGF-β信号通路调控

Galunisertib (LY2157299), a selective ATP-mimetic inhibitor of TGF-β receptor I (TGF-βRI), is the only known TGF-β pathway inhibitor. In the present study, we investigated the effect of galunisertib o

NIAID Data Ecosystem80

A High-dose of genistein down-regulates TGF-beta pathway genes in human uterine leiomyoma cells

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