NRXNs bind SYTs

Synaptotagmins (SYTs) are transmembrane proteins involved in membrane trafficking and calcium-dependent exocytosis of synaptic vesicles at the synapse. SYTs may mediate this by binding to presynaptic proteins, the neurexins (NRXNs) (Perin 1994, Hata et al. 1993, Petrenko et al. 1991). The interaction between these two proteins may mediate part of the recognition of presynaptic active sites by synaptic vesicles or may regulate neurotransmitter release (Perin 1996).

突触标签蛋白（Synaptotagmins，简称SYTs）是一类跨膜蛋白，其在突触的膜转运以及依赖于钙离子的突触囊泡外排过程中发挥着关键作用。这些蛋白可能通过结合突触前蛋白，如神经突触蛋白（Neurexins，简称NRXNs）（Perin 1994，Hata 等人 1993，Petrenko 等人 1991）来介导这一过程。这两种蛋白之间的相互作用可能部分介导突触囊泡对突触前活性位点的识别，或调节神经递质的释放（Perin 1996）。