Controlled release of Doxorubicin from poly(lactic-co-glycolic acid) (PLGA) nanoparticles prepared by coaxial electrospraying

Matrix and core-shell doxorubicin-loaded nanoparticles were produced by single and coaxial electrospraying technique. The drug release and cytotoxicity assays of free DOX and nanoparticles are studied. The drug release from the nanoparticles was determined using a dialysis method, which is a common and recommended method for assessing drug release from nanoparticles. The cytotoxicity of free DOX, blank PLGA NPs, matrix DOX-loaded NPs and core-shell DOX-loaded NPs was measured by MTT assay. The raw data of the results are shown here.

采用单喷和同轴电喷雾技术制备了矩阵-核壳型阿霉素载药纳米颗粒。对游离阿霉素和纳米颗粒的药物释放和细胞毒性进行了研究。纳米颗粒的药物释放通过透析法测定，该法是评估纳米颗粒药物释放的常用且推荐的方法。游离阿霉素、空白PLGA纳米颗粒、矩阵型阿霉素载药纳米颗粒和核壳型阿霉素载药纳米颗粒的细胞毒性通过MTT法进行测量。结果显示的原始数据如下。