Letter to JTD Bliss 9groups N =15

The study by Nanjin Chen et al provided interesting and novel data on the effective dose and gender differences of alfentanil in painless bronchoscopy, and their results suggested that there were no obvious differences of the effective dose of alfentanil(ED50 value) between men and women. Our similar study agreed the authors' findings that the optimal dose of alfentanil required for painless bronchoscopy was significantly higher than some other studies, but did not support their conclusion that there was no gender difference in alfentanil. Considering that the gender difference of alfentanil has a great impact on its clinical application, further research is needed to confirm this discrepancy, just as the authors pointed out, future studies are needed to investigate the analgesic effects of alfentanil at different doses and in the different genders with multi-center and large-sample studies.