GSE44742: Genetic differences underlying chromatin discordance between monozygotic twins

Summary: Open chromatin is implicated in regulatory processes, and thus variation in chromatin structure may contribute to variation in gene expression and other molecular phenotypes. In this work, we performed a targeted deep sequencing to identify somatic mutations and genetic polymorphisms underlying accessible chromatin in the genomes of 72 monozygotic twins. Overall Design: Open chromatin sequencing based on FAIRE assay for 36 pairs of monozygotic twins