In this dataset, we evalute the effect of modulating the levels of LSD1 in the PS19 tauopathy mouse (mouse that expresses the P301S mutated form of the human tau transgene). First we reduced the level
We investigated the effects of human tau on subcellular populations of the brain mitochondrial proteome in vivo using transgenic htau mice at ages preceding (5 months) and coinciding with (8 months) o
Tau35 is a truncated form of tau found in human brain in a subset of tauopathies. Tau35 expression in mice recapitulates key features of human disease, including progressive increase in tau phosphoryl
We report the development of a novel 3D human induced pluipotent stem cell derived neural-glial coculture model of tauopathy and identify pathways associated with pathogenesis by 10X 3' single cell RN
