Medulloblastoma is the most common form of malignant paediatric brain tumour and is the leading cause of childhood cancer related mortality. The four molecular subgroups of medulloblastoma that have b
Pineoblastoma is a rare and aggressive embryonal tumor of childhood. The molecular heterogeneity within has not been systematically evaluated. In this study, we used methylation profiling to compare t
Many facets of the tumor biology of medulloblastoma (MB) have not been fully elucidated. Collapsin response mediator protein 1 (CRMP1) is a member of cytoplasmic family of proteins that regulate the d
RNA sequencing was performed on Group 3 medulloblastoma tumorspheres expressing high vs. low levels of OTX2. Overall design: OTX2 levels were knocked down in HDMB03 and MB3W1 Group 3 MB cells (2X10^5