Experiment Design.

Definition of abbreviations: J = TMC 207, R = Rifampin, M = Moxifloxacin, H = Isoniazid, Z = Pyrazinamide, A = amikacin, Et = ethionamide.Mice were infected intravenously with 1.1×106 of M. tuberculosis H37Rv.Day -18: the day after infection, Day 0: start of treatment.*Mice kept untreated for mortality assessment.All drugs were given 5 times per week at the following doses: J, 25 mg/kg; R, 10 mg/kg; M, 100 mg/kg; H, 25 mg/kg; Z, 150 mg/kg; A, 150 mg/kg; Et, 50 mg/kg.