Rhodium-Catalyzed Room Temperature C–C Activation of Cyclopropanol for One-Step Access to Diverse 1,6-Diketones

A rhodium-catalyzed
room temperature C–C activation of cyclopropanol
has been demonstrated for the single-step synthesis of a range of
electronically and sterically distinct 1,6-diketones. This reaction
proceeds efficiently in shorter reaction time following a highly atom-economical
pathway. To illustrate the synthetic potential of 1,6-diketones, aldol
and macrocyclization reactions have been successfully demonstrated.
Preliminary mechanistic studies revealed the involvement of nonradical
pathways.