Metadata record for the manuscript: Synergistic activation of mutant TERT promoter by Sp1 and GABPA in BRAFV600E-driven human cancers

<b>Summary</b>

This
metadata record provides details of the data supporting the claims of the
related manuscript: “Synergistic activation of mutant TERT
promoter by Sp1 and GABPA in BRAFV600E-driven human cancers”.

The
data consist of 31 Excel .xlsx format spreadsheets and a Word .docx document.

The
related study tested the hypothesis that activated extracellular
signal-regulated kinase (ERK) may be recruited to mutant telomerase reverse
transcriptase (TERT) promoter by pioneer transcription factors.

<b>Data
access</b>

The
31 Excel .xlsx spreadsheets underlie the figures in the related manuscript, and
are named according to the figure and subfigure they underlie (e.g., Figure 1B
1.xlsx). These are openly available and are included together with this metadata record, and they contain data concerning qRT-PCR, dual-luciferase reporter assay, ChIP and TRAP assays described in the related manuscript. The sequence homology analsysis (underlying
Supplementary Figure 8) is openly available and is also included together with this
metadata record. Data for the Co-IP assay supporting Figure 3 are in the file WB-CoIPs.tiff and are available upon request to the corresponding author, Prof. Peng Hou: [e-mail].