Virome profile in acute febrile illness patients using metagenomic Next-Generation Sequencing: A systematic review, meta-analysis and Torque Teno Virus abundance in Northeastern Thailand

This study aimed to identify viruses present in AFI patients via metagenomic next-generation sequencing (mNGS) through meta-analysis. The publications were retrieved from three databases, including PubMed, Scopus and ScienceDirect. Five publications [1-5] that met our specific inclusion criteria and used mNGS to examine the virome in AFI plasma and serum specimens were eligible for this systematic review. The sample size of the studies included in this meta-analysis varied significantly, ranging from 12 to 816 cases. Of the five studies were cross-sectional studies. All three studies reported detailed information on the age distribution of AFI patients. The geographical distribution of the study population was two studies conducted in America, one in Africa and two in Europe. All studies used plasma or serum for the NGS method, with or without RT-PCR.

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