TLR4 signaling and tolerance

This pathway is based on the figure 2 of "Toll-like Receptors: Novel Pharmacological Targets for the Treatment of Neurological Diseases" and figure 2 of "Toll-like receptor and its roles in myocardial ischemic/reperfusion injury" (see bibliography). The Toll-like receptors are used by mammals to recognize pathogen-associated molecules such as the cell wall components. The activation of TLR4 causes a cell's inability to produce TNFa. TLR4 deals with MyD88 independent and dependent pathways, and due to LPS tolerant cells, inhibitors of the MyD88 dependent pathway are increased. TLR is important in the creation of protective immune responses to cancers, and the protection of brain tissue from injury. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3851 CPTAC Assay Portal].

本路径基于《Toll 样受体：治疗神经系统疾病的新型药理学靶点》一书中图 2 以及《Toll 样受体及其在心肌缺血/再灌注损伤中的作用》一书中图 2（参见参考文献）。哺乳动物利用 Toll 样受体识别病原相关分子，如细胞壁成分。TLR4 的激活导致细胞无法产生 TNFa。TLR4 处理 MyD88 依赖性和非依赖性途径，由于对脂多糖（LPS）耐受的细胞增多，MyD88 依赖性途径的抑制剂增加。Toll 样受体在产生针对癌症的保护性免疫反应以及保护脑组织免受损伤方面具有重要意义。该路径上的蛋白质具有通过 [https://assays.cancer.gov/available_assays?wp_id=WP3851 CPTAC 测定法门户] 可用的靶向测定方法。