Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase

Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase Descriptor: Glycogen phosphorylase, muscle form, N-acetyl-beta-D-glucopyranosylamine, ... Authors: Anagnostou, E, Kosmopoulou, M.N, Chrysina, E.D, Leonidas, D.D, Hadjiloi, T, Tiraidis, C, Zographos, S.E, Gyorgydeak, Z, Somsak, L, Docsa, T, Gergely, P, Kolisis, F.N, Oikonomakos, N.G. Deposit date: 2004-12-30 Release date: 2005-12-13 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-d-glucopyranosylamine and N-trifluoroacetyl-beta-d-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase Bioorg.Med.Chem., 14, 2006

针对两种生物等排类似物（bioisosteric analogues）——N-乙酰基-β-D-吡喃葡萄糖基胺（N-acetyl-beta-D-glucopyranosylamine）与N-三氟乙酰基-β-D-吡喃葡萄糖基胺（N-trifluoroacetyl-beta-D-glucopyranosylamine）——开展的晶体学研究，二者均为强效肌肉糖原磷酸化酶（muscle glycogen phosphorylase）抑制剂。
描述符：肌肉型糖原磷酸化酶、N-乙酰基-β-D-吡喃葡萄糖基胺……
作者：Anagnostou, E、Kosmopoulou, M.N、Chrysina, E.D、Leonidas, D.D、Hadjiloi, T、Tiraidis, C、Zographos, S.E、Gyorgydeak, Z、Somsak, L、Docsa, T、Gergely, P、Kolisis, F.N、Oikonomakos, N.G
入库日期：2004-12-30
发布日期：2005-12-13
最后修改日期：2023-10-25
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.9 Å
引用文献：《针对两种强效肌肉糖原磷酸化酶抑制剂类生物等排类似物的晶体学研究》，发表于《Bioorg.Med.Chem.》2006年第14卷。