Comparison of the lead-SNPs identified here and eQTL.

eQTL data derived from ‘Whole blood’ from GTEx [19] (v7). Bonferroni correction 0.05/54. Columns are ‘hgnc_symbol’: the HGNC symbol corresponding to the UniProtID; ‘rsid’: rsID of the SNP; ‘chr’: chromosome of the SNP, GRCh37; ‘pos’: position of the SNP, GRCh37; ‘a1’: the effect allele; ‘a0’: the other allele; ‘uniprot’: UniProtID of the protein; ‘n_protein_pri’: number of individuals in the primary protein cohort (CROATIA-Vis); ‘freq1_protein_pri’: frequency of the effect allele in the primary protein cohort (CROATIA-Vis); ‘beta1_protein_pri’: effect-size estimate in the primary protein cohort (CROATIA-Vis); ‘se_protein_pri’: standard error of ‘beta1_protein_pri’; ‘p_protein_pri’: p-value of ‘beta1_protein_pri’ and ‘se_protein_pri’; ‘info_protein_pri’: SNPTEST (v2) imputation info score in the primary protein cohort (CROATIA-Vis); ‘n_protein_sec’: as for the primary cohort (CROATIA-Vis) but in the secondary cohort (ORCADES); ‘freq1_protein_sec’: as for the primary cohort (CROATIA-Vis) but in the secondary cohort (ORCADES); ‘beta1_protein_sec’: as for the primary cohort (CROATIA-Vis) but in the secondary cohort (ORCADES); ‘se_protein_sec’: as for the primary cohort (CROATIA-Vis) but in the secondary cohort (ORCADES); ‘p_protein_sec’: as for the primary cohort (CROATIA-Vis) but in the secondary cohort (ORCADES); ‘info_protein_sec’: as for the primary cohort (CROATIA-Vis) but in the secondary cohort (ORCADES); ‘ensembl_gene_id’: Ensembl gene ID corresponding to the protein; ‘pval_nominal_gtex’: nominal p-value in GTEx (v7) whole blood; ‘slope_gtex’: effect-size estimate in GTEx (v7) whole blood; ‘slope_se_gtex’: standard error of ‘slope_gtex’ in GTEx (v7) whole blood; ‘pval_nominal_threshold_gtex’: nominal p-value threshold for calling a variant-gene pair significant for the gene in GTEx (v7) whole blood; ‘min_pval_nominal_gtex’: smallest nominal p-value for the gene in GTEx (v7) whole blood; ‘pval_beta’: beta-approximated permutation p-value for the gene in GTEx (v7) whole blood. (TSV)