GRADE Evidence Profile for insulin glargine versus non-glargine insulin.

*Only some studies presenting effect estimates adjusted for known confounders.
†High heterogeneity among studies.
‡95% confidence interval around the pooled includes both 1) no effect and 2) appreciable benefit and appreciable harm.
§Although we did not downgrade, publication bias cannot be excluded.
∥95% confidence interval around the pooled includes both 1) no effect and 2) appreciable harm.
¶95% confidence interval around the pooled includes both 1) no effect and 2) appreciable benefit.