Crystal structure of PDE9 in complex with racemic inhibitor C33

Crystal structure of PDE9 in complex with racemic inhibitor C33 Descriptor: 6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, 6-{[(1S)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ... Authors: Huang, M. Deposit date: 2015-02-16 Release date: 2015-09-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol.Pharmacol., 88, 2015PDE9与外消旋抑制剂C33复合物的晶体结构 描述：6-{[(1R)-1-(4-氯苯基)乙基]氨基}-1-环戊基-1,5-二氢-4H-吡唑并[3,4-d]嘧啶-4-酮、6-{[(1S)-1-(4-氯苯基)乙基]氨基}-1-环戊基-1,5-二氢-4H-吡唑并[3,4-d]嘧啶-4-酮、高亲和力cGMP特异性3',5'-环磷酸二酯酶9A（High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A）…… 作者：黄（Huang, M.） 提交日期：2015-02-16 发布日期：2015-09-16 最后修改日期：2024-02-28 实验方法：X射线衍射（2.01埃） 引用文献：《磷酸二酯酶9A的结构不对称性及强效对映异构体抑制剂选择性结合的独特口袋》，《分子药理学（Mol.Pharmacol.）》，第88卷，2015年