Additional file 6 of Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation

Additional file 6: Supplementary Tables: Table S1. Characteristics of the study subsample and of the full NICHD fetal Growth Studies – Singletons. Table S2: Description of the maternal plasma persistent organic pollutants concentrations. TableS3: Top-significant adjusted difference (BACON-corrected FDR p-values < 0.05) in placenta DNA methylation associated with maternal POP. Table S4: Differentially methylated regions (DMR) analysis. TableS5: Correlations between DNA methylation at the top differentially methylated CpG sites and gene expression in placenta. Table S6: Significant associations between maternal blood levels of POP and expression of genes near the top significant DNA methylation CpG sites. Table S7: Top 10 pathways of diseases and biological function from IPA. TableS8: IPA Canonical Pathway. Table S9: Network identified by Ingenuity Pathway Analysis. Table S10: Placental cis-eQTL analysis of top-significant (Bacon-adjusted FDR P-value<0.05) CpGs. Table S11: Cis-meQTL analysis of top-significant (Bacon-adjusted FDR P-value<0.05) CpGs. Table S12: Spearman correlation between top differentially methylated CpG sites and neonatal anthropometry. Table S13: Spearman correlation between neonatal anthropometry and gene-expression that were significantly correlated with the methylation on the corresponding CpG sites. Table S14: Comparison with previous EWAS on chemicals. Table S15: Sensibility analysis further adjusted for clinical sites for the CpG sites differentially methylated in the original model.