Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM1153 (4,6-dicyclopropyl-3-(3-fluoro-4-(trifluoromethyl)benzyl)-2-methyl-2,6-dihydro-7H-pyrazolo[3,4-d]pyridazin-7-one)

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM1153 (4,6-dicyclopropyl-3-(3-fluoro-4-(trifluoromethyl)benzyl)-2-methyl-2,6-dihydro-7H-pyrazolo[3,4-d]pyridazin-7-one) Descriptor: 4,6-dicyclopropyl-3-{[3-fluoro-4-(trifluoromethyl)phenyl]methyl}-2-methyl-2,6-dihydro-7H-pyrazolo[3,4-d]pyridazin-7-one, 6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione, Dihydroorotate dehydrogenase (quinone), ... Authors: Deng, X, Tomchic, D, Phillips, M. Deposit date: 2024-09-09 Release date: 2025-01-01 Last modified: 2025-01-22 Method: X-RAY DIFFRACTION (3.15 Å) Cite: Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention. J.Med.Chem., 68, 2025恶性疟原虫（*Plasmodium falciparum*）二氢乳清酸脱氢酶（dihydroorotate dehydrogenase, DHODH）结合抑制剂DSM1153（4,6-二环丙基-3-(3-氟-4-(三氟甲基)苄基)-2-甲基-2,6-二氢-7H-吡唑并[3,4-d]哒嗪-7-酮）的晶体结构。描述项：4,6-二环丙基-3-{[3-氟-4-(三氟甲基)苯基]甲基}-2-甲基-2,6-二氢-7H-吡唑并[3,4-d]哒嗪-7-酮、6-(二羟甲基)-5H-嘧啶-2,4-二酮、醌依赖型二氢乳清酸脱氢酶…… 作者：邓X、Tomchic D、Phillips M。提交日期：2024-09-09；发布日期：2025-01-01；最后修改日期：2025-01-22。实验方法：X射线衍射法（3.15埃）。引用文献：《基于结构的疟疾化学预防用高效二氢乳清酸脱氢酶抑制剂的发现与开发》，《药物化学杂志》（*J. Med. Chem.*），第68卷，2025年。